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Glucose-6-phosphate dehydrogenase deficiency in malaria endemic areas in the Philippines.


Crispin  P. Echiverri,
Myrna R. Acacio ,
Andres S. Cubacub ,
Marietta C. Baccay ,
Adoracion Z. Reyes ,
Fermin A. Talao ,
Nelia P. Salazar

Related Institution

Research Institute for Tropical Medicine

V. Luna Medical Center

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Publication Information

Publication Type
Research Report


Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, a hereditary biochemical defect of erythrocytes, was detected among residents of malaria endemic areas on the big island of Luzon, Republic of the Philippines. A total of 774 individuals were examined, 1.5 to 68 years old consisting of 485 males and 289 females. The overall prevalence rate of 5.5% among Filipinos concurred with data from previous studies. Pedigrees of selected families showed a Mendelian pattern of inheritance. The potential hazard of treating G-6-PD deficient patients with antimalarials such as primaquine, sulfonamide, sulfones, quinidine, and quinine, or combination thereof, is recognized.


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