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Non-HPV associated adenosquamous cervical carcinoma in a 54-year old virgin.

Author

Niña Marla L. Abellera,
Rafael S. Tomacruz,
Nepthali M. Gorgonio,
Ma. Patricia L. Luna-Sun

Related Institution

Department of Obstetrics and Gynecology - Cardinal Santos Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Case report
Title
Philippine Journal of Obstetrics and Gynecology
Frequency
Quarterly
Publication Date
April-June 2010
Volume
34
Issue
2
Page(s)
82-89

Abstract

A 54-year old, single, nulligravid, without history of sexual contact, was admitted due to postmenopausal bleeding. Transrectal ultrasound revealed myoma uteri and thickened endometrium. She was thus scheduled to undergo endometrial curettage. However, prior to the performance of the endometrial sampling procedure, there was profuse vaginal bleeding with note of a possible prolapsed submucous myoma. She thus underwent emergency exploratory laparotomy with total hysterectomy and bilateral salpingooophorectomy.


Intraoperatively, necrotic masses were noted within the endocervical canal. Frozen section of the uterus and these masses revealed malignancy. Intraoperative referral to a gynecologic oncologist was done and bilateral pelvic lymphadenectomy and surgical staging were performed. Final histopathologic report revealed Cervical Adenosquamous Carcinoma. She subsequently underwent external beam radiotherapy and vaginal brachytherapy.


With the knowledge that almost all cases of cervical cancer is due to the Human Papilloma Virus (HPV), that this virus is almost exclusively transmitted by sexual contact, and the fact that she never engaged in sexual practices, there was doubt as to the source of the cancer. To help resolve this issue, an HPV DNA Polymerase Chain Reaction assay was performed on paraffin block samples and these all turned out negative for HPV. She may possess one of the rarest forms of cervical cancer - one that is not associated with the Human Papilloma Virus.

References

1. Ladines-Llave, C. , Almaria, M J.. Cervical Cancer Prevention (CECAP) Network Program. 2009.
2. Canavan, T P., Canavan, T P., Doshi, N R., Doshi, N R.. "Cervical cancer." Am Fam Physician 61((5)): 1369-1376, 2001
3. Canavan, T P., Canavan, T P., Doshi, N R., Doshi, N R.. "Cervical cancer." Am Fam Physician 61((5)): 1369-1376, 2001
4. Muñoz, N. , Muñoz, N. , Bosch, F X., Bosch, F X., de Sanjose, S. , de Sanjose, S. , Herrero, R. , Herrero, R. , Castellsague, X. , Castellsague, X. , Shah, K V., Shah, K V., Snijders, P J., Snijders, P J., Meijer, C J., Meijer, C J.. "Epidemiological classification of human papillomavirus type associated with cervical cancer." N Engl J Med 348((6)): 518-527, 2003
5. Muñoz, N. , Muñoz, N. , Bosch, F X., Bosch, F X., de Sanjose, S. , de Sanjose, S. , Herrero, R. , Herrero, R. , Castellsague, X. , Castellsague, X. , Shah, K V., Shah, K V., Snijders, P J., Snijders, P J., Meijer, C J., Meijer, C J.. "Epidemiological classification of human papillomavirus type associated with cervical cancer." N Engl J Med 348((6)): 518-527, 2003
6. Unpublished Data, 2007 Annual Statistics of the Section Gynecologic Oncology, UP-PGH..
7. Unpublished Data, 2007 Annual Statistics of the Section Gynecologic Oncology, UP-PGH..
8. Durst, M. , Durst, M. , Gissman, L. , Gissman, L. , Ikenberg, H. , Ikenberg, H. , zur Haussen, H. , zur Haussen, H. . A papllomavirus DNA from a cervical carcinoma and its prvalence in cancer biopsy samples from different geographic regions. Proceedings of the NAtional Academy Sciences of the United States of America..
9. Durst, M. , Durst, M. , Gissman, L. , Gissman, L. , Ikenberg, H. , Ikenberg, H. , zur Haussen, H. , zur Haussen, H. . A papllomavirus DNA from a cervical carcinoma and its prvalence in cancer biopsy samples from different geographic regions. Proceedings of the NAtional Academy Sciences of the United States of America..
10. What causes cancer of the cervix?. American Cancer Society, 2026. 11-30.
11. What causes cancer of the cervix?. American Cancer Society, 2026. 11-30.
12. HPV type-detect.. Diagnostic Laboratories. 2007. 10-30.
13. HPV type-detect.. Diagnostic Laboratories. 2007. 10-30.
14. A Primer n HPV. Benchmarks. National Cancer Institute,
15. A Primer n HPV. Benchmarks. National Cancer Institute,
16. Snijders, P J., Steenberg, R D., Heideman, D A., Meijer, C J., Snijders, P J., Steenberg, R D., Heideman, D A., Meijer, C J.. "HPV-mediated cervical carcinogenesis: concepts and clinical implications." J Pathol 208((2)): 152-164, 2006
17. Snijders, P J., Steenberg, R D., Heideman, D A., Meijer, C J., Snijders, P J., Steenberg, R D., Heideman, D A., Meijer, C J.. "HPV-mediated cervical carcinogenesis: concepts and clinical implications." J Pathol 208((2)): 152-164, 2006
18. Walboomers, J M., Jacobs, M V., Mannos, M M., Walboomers, J M., Jacobs, M V., Mannos, M M.. "Human papillomavirus is a necessary causes of invasive cervical cancer worldwide." J Pathol 189((1)): 12-19, 1999
19. Walboomers, J M., Jacobs, M V., Mannos, M M., Walboomers, J M., Jacobs, M V., Mannos, M M.. "Human papillomavirus is a necessary causes of invasive cervical cancer worldwide." J Pathol 189((1)): 12-19, 1999
20. Weimin, Q U., Gang, J. , Yvette, C. , Weimin, Q U., Gang, J. , Yvette, C. . "PCR dtection of human papillovirusses: comparison between MY09/MY11 and GP51/GP61 primer systems." J Clin Microbiol 35, 1304-1310, 1997
21. Weimin, Q U., Gang, J. , Yvette, C. , Weimin, Q U., Gang, J. , Yvette, C. . "PCR dtection of human papillovirusses: comparison between MY09/MY11 and GP51/GP61 primer systems." J Clin Microbiol 35, 1304-1310, 1997
22. Griffiths, M. , Griffiths, M. . Nuns, virgins and spinsters..
23. Griffiths, M. , Griffiths, M. . Nuns, virgins and spinsters..
24. Tiro, J A., Meissner, H I., Kobrin, S. , Chollette, V. , Tiro, J A., Meissner, H I., Kobrin, S. , Chollette, V. . "What do men in the U.S know about human papilloma virus and cervical cancer?" Cancer Epidemiol Biomarkers Prev 16((2)): 288-94, 2007
25. Tiro, J A., Meissner, H I., Kobrin, S. , Chollette, V. , Tiro, J A., Meissner, H I., Kobrin, S. , Chollette, V. . "What do men in the U.S know about human papilloma virus and cervical cancer?" Cancer Epidemiol Biomarkers Prev 16((2)): 288-94, 2007
26. Matthews-Greer, , Matthews-Greer, . Human papillomavirus typing of rare cervical carcinomas.. Arch Patho Lab Med. Department of Pathology, Louisiana State University Health Sciences, Shreveport. USA:
27. Matthews-Greer, , Matthews-Greer, . Human papillomavirus typing of rare cervical carcinomas.. Arch Patho Lab Med. Department of Pathology, Louisiana State University Health Sciences, Shreveport. USA:

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Philippine Council for Health Research and Development Library Box No. 52 Fulltext pdf (Request Document)

 
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