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A case series using methylene blue for sentinel lymph node biopsy in breast cancer at St. Luke's Medical Center.

Author

Jonathan C. Nolasco,
Ma. Cecilia  Pagdanganan

Related Institution

Department of Surgery - St. Luke's Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Case Series
Title
Philippine Journal of Surgical Specialties
Frequency
Quarterly
Publication Date
April-June 2010
Volume
65
Issue
2
Page(s)
67-69

Abstract

Sentinel lymph node biopsy has not gained popularity in the Philippines, perhaps the reason being the unavailability of resources. The use of methylene blue may change this situation.
OBJECTIVE: The authors intend to demonstrate that methylene blue may be used as an alternative dye in sentinel lymph node biopsy for breast cancer with satisfactory results.
METHODS: Twenty patients diagnosed with breast cancer underwent sentinel lymph node biopsy after injection with methylene blue dye, followed by complete axillary dissection. Histologic evaluation of the nodes was done using H&E stain.
RESULTS: The identification rate was 95%, with no false negatives.
CONCLUSION: Sentinel lymph node biopsy using methylene blue can be done with satisfactory results.

References

1. Giuliano, AE , Korgan, DM , Guenther, JM , Morton, DL . "Lymphatic mapping and sentinel lymphadenoectomy for breast cancer" Ann Surg 220, 391-398, 1994. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234400/
2. Nolasco, JC , Pagdanganan, MC , Dizon, AC , Galang, CJ , Gonzales, FC , Ramos, NL . "Sentinel lymph node biopsy in breast cancer using methylene blue: a preliminary report" St. Luke 2(2): 15-18, 2003
3. Cruz, MD , Qua, JC , Lao, LL . "Accuracy of isosulfan blue dye in sentinel node biopsy for breast cancer" Phillip J Surg Spec 63(2): 66-71, 2008
4. Nos, C , Freneaux, , Guilber, S , Falcon, MC , Salmon, RJ , Clough, KB . "Sentinel lymph node detection for breast cancer: which patients are best suited for the patent blue dye only method of identification" Ann Surg Oncol 8(5): 438-443, 2001
5. Thevarajah, S , Huston, TL , Simmons, RM . "A comparison of the adverse reactions associated with isosulfan blue vs methylene blue dye in sentinel lymphadenectomy for breast cancer" Am J Surg 189, 236-239, 2005
6. Stefanutto, TB , Shapiro, WA , Wright, PM . "Anaphylactic reaction to isosulfan blue" Br J Anesth 89(3): 527-528, 2002
7. Blessing, WD , Stolier, AJ , Teng, SC , Bolton, JS , Fuhrman, GM . "A comparison of methylene blue and lymphazurin in breast sentinel node mapping" Am J Surg 184, 341-345, 2002. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/12383897
8. Borgstein, PJ . "Sentinel lymph node biopsy in breast cancer: guidelines and pitfalls of lymphoscintigraphy and gamma probc detection" J Am Coll Surg 186, 275-283, 1998
9. Nour, A . "Efficacy of methylene blue dye in localization of sentinel lymph node in breast cancer patients" Breast J 10(5): 388-391, 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15327490

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext pdf (Request Document)

 
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