Report an error   
Advanced Search

The anti-inflammatory activity of the flavonoid extract of Artocarpus heterophyllus Lam. (jackfruit) leaves on male Mus musculus (albino mice).


Artina C. Aquitania,
Estrelle Marie D. Cabanes,
Colleen M. Natividad,
Yedda Marie L. Tausa,
Shay Maries T. Yu,
Jan Harmony  A. Cesar

Related Institution

College of Pharmacy - Cebu Doctors' University

Publication Information

Publication Type
Thesis Degree
Publication Date
March 2016


     This study was done to determine the anti-inflammatory effect of the extract from the leaves of Artocarpus heterophyllus Lam. (Jackfruit) using randomized controlled trial. The study was conducted in the Animal Research Laboratory, Cebu Doctors‟ University, Mandaue City. We utilized 30 male albino mice by randomly grouping them into their assigned treatment, which was the test solution group, negative control group, and the positive control group. The test subjects were healthy male Mus musculus (albino mice) that were acclimatized for two weeks prior to experimentation period. All the test animals were administered subcutaneously with carrageenan solution to induce inflammation. Each mouse was given a single dose after measuring its right hind paw inflammation. The mice assigned to the experimental group were given the solution from the Artocarpus heterophyllus Lam. (Jackfruit) leaves, those assigned to the positive control group were given Ponstan suspension, and those assigned in negative control group distilled water. After an hour, the inflammation was measured and for the other following hours in a span for 6 hours.

    The right hind paw sizes of all thirty male albino mice varied before and after induction of inflammation. The positive group which was administered with Ponstan showed the highest mean difference in the paw size, as next to it was the experimental group in which the Artocarpus heterophyllus Lam. (Jackfruit) leaves extract was administered, and the least among the three was the negative control which was administered with distilled water, that was to  determine the natural healing ability of the test animals.

     We concluded that the anti-inflammatory effect of the flavonoid which was extracted from Jackfruit leaves and administered to the carrageenan-induced male albino mice is comparable to the effect of Mefenamic Acid (Ponstan). The researchers would recommend to have an extensive study to determine the specific flavonoid responsible for the anti-inflammatory effect of jackfruit extract, a study on the toxicity level of the Jackfruit leaves extract, study on its pregnancy safety and its‟ therapeutic index, and a research on its pharmacodynamics and further pharmacokinetics.


3. Augustsson, H. . Ethoexperimental studies of behaviour in wild and laboratory mice: Risk assessment, Emotional reactivity, and animal welfare. 2004. 1401-6257. Swedish University of Agricultural Sciences, . Retrieved from: http://pub.epsilon.slu.se/531/
4. California Rare Frui, . (1995, November 30). Jackfruit. . Retrieved from: http://www.ctahr.hawaii.edu/sustainag/extn_pub/fruitpubs/Jackfruit%20Fruit%20Facts.pdf
5. Doctor, T. , Manuel, J. . "Phytochemical screening of selected indigenous medicinal plants of Tublay, Benguet Procvince, Cordillera Administrative Region,Philippines." International Journal of Scientific and Research Publications 4(4): 1-12, 2014. Retrieved from: http://www.ijsrp.org/research-paper-0414/ijsrpp2826.pdf
6. Egert, S. , Rimbach, G. . (2010, November 30). Which sources of flavonoids:Complex or Dietary Supplements. . Retrieved from: http://advances.nutrition.org/content/2/1/8.full
7. Fang, S. , Hsu, , Chin-Lin, H. , Gow-Chin, Y. . (2007, November 30). Antiinflammatory Effects of Phenolic Compounds Isolated from the fruits of Artocarpusheterophyllus. . Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/18500810
8. Finkel, R. , Cubeddu, L. , Clark, M. . Pharmacology (4thed.) Philadelphia: Lippincott William & Wilkins, 2009.
10. Kornfeld, R. . (2010, November 30). Five ways to reduce inflammation. Huff post Healthy Living. . Retrieved from: http://www.huffingtonpost.com/dr-robert-a-kornfeld/5-waysto-reduce-inflamma_b_271640.html
11. New Zealand Medicine, . (2012, November 30). New Zealand data sheet: Ponstan. . Retrieved from: http://www.medsafe.govt.nz/profs/datasheet/p/Ponstancap.pdf
13. Kumar, S. , Pandey, A. . "Chemistry and biologicalactivities of flavonoids: An overview" The scientific world journal 2013(2013): 1-16, 2013. Retrieved from: http://www.hindawi.com/journals/tswj/2013/162750/
14. Ngujo, P. , Santos, T. , Mutia, M. , Cubos, J. , Arriola, M. . Anti-Inflammatory effects of triterpenoids saponin extracted fromtambis leaves (Syzygium samarangenese) in female albino rabbits(Oryctolagus cuniculusLinne.). Mandaue City, Cebu. 2014. Cebu Doctors‟ University,
15. Nordqvist, C. . (2014, November 30). Inflammation: causes, symptoms and treatment. . Retrieved from: http://www.medicalnewstoday.com/articles/248423.php
16. Omar, H. , El-Beshbishy, H. A. , Moussa, Z. , Taha, K. F. , Singab, A. N. . "Antioxidant activity of Artocarpus heterophyllusLam. (Jackfruit) leaf extracts: remarkable attenuations ofhyperglycemia and hyperlipidemia in streptozotocin-diabeticrats" Scientific World Journal 5(11): 788-800, 2011. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/21479350
17. Pandey, A. , Tripathi, S. . "Concept of standardization,extraction and pre phytochemical screening strategies for herbal drug" Journal of Pharmacognosy and Phytochemistry 2(5): 115-119, 2014. Retrieved from: http://www.phytojournal.com/vol2Issue5/Issue_jan_2014/11.pdf
18. McGettigan, P. , Henry, D. . (2012, November 30). Use of non-steroidal antiinflammatory drugs that elevate cardiovascular risk: An examination of sales and essential medicine list in low,middle, and high income countries. . Retrieved from: http://www.who.int/selection_medicines/committees/expert/19/applications/Naproxen_Addendum_1.pdf
19. Prakash, O. , Kumar, R. , Mishra, A. , Gupta, R. . "Artocarpusheterophyllus (Jackfruit): An overview.Review" Pharmacognsy 3(6): 353-358, 2010. Retrieved from: http://www.phcogrev.com/article.asp?issn=09737847%3Byear%3D2009%3Bvolume%3D3%3Bissue%3D6%3Bspage%3D353%3Bepage%3D358%3Baulast%3DPraksh
22. Yusuf , A. , Zakir, A. , Shemau, Z. , Abdullahi, M. , Halima, S. A. . "Phytochemical analysis of the methanol leavesextract of Paulina pinnata Linn. " Journal of Pharmacognosy and Phythotherapy 6(2): 10-16, 2013. Retrieved from: http://www.academicjournals.org/article/article1390401671_Yusuf%20et%20al.pdf

Physical Location

LocationLocation CodeAvailable FormatAvailability
Cebu Doctors' University - Main Library U8 An87aq 2016 Fulltext Print Format

©2022 HERDIN PLUS. All rights reserved. | Contact Us | Keep up to date