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Hypoglycemic effect of Jasminum sambac (Sampaguita) leaf extract on the blood glucose level of dexamethasone-induced Mus musculus (albino mice).


Deanne Norelle Mae S. Dumdum,
Leaville Kaye C. Flores,
Joseann Danica Mae B. Roxas,
Judy Jane B. Sialmo,
Vivian Kayee M. Villarino,
Filconey Rose B. Camado

Related Institution

College of Allied Medical Sciences - Medical Technology Department - Cebu Doctors' University

Publication Information

Publication Type
Thesis Degree
Medical Technology
Publication Date
December 2017


          This study aimed to determine the hypoglycemic effect of Sampaguita Leaf Extract (Jasminum sambac) on the blood glucose level of Dexamethasone-Induced Albino Mice (Mus musculus). This is an experimental study that utilized the randomized controlled trial in evaluating the effects of Sampaguita Leaf Extract (Jasminum sambac) on the blood glucose level of Dexamethasone-induced albino mice. The study utilized sixteen (16) healthy male albino mice weighing 20 to 30g with normal blood glucose levels within 60-130mg/dl and with no other abnormalities. The albino mice were acclimatized for a period of fourteen (14) days and baseline glucose levels were determined on the fifteenth day. After the acclimatization period, the mice were injected intraperitoneally with 1 mg/kg of Dexamethasone for seven (7) days to increase the blood glucose level to above 130 mg/dl. After injection of dexamethasone, the subjects were assigned randomly into two groups, with eight (8) mice per group: the positive control group and the experimental group of 100% concentration of Sampaguita leaf extract. The subjects were given treatment for seven (7) days. Blood extraction was done after the 7th day of treatment.
          The albino mice treated with 100% Sampaguita leaf extract revealed a mean blood glucose (mg/dl) of 71.75±29.23 on the 8th day. While the metformin group showed a mean blood glucose of 76.63±11.03. Both post-treatment blood glucose levels are still within the normal range. Independent t-test revealed that there was no significant difference in the blood glucose levels (mg/dl) between the Sampaguita extract and metformin groups at 0.05 level of significance on the 8th day of post-treatment, t(14) = -.441 and p > .05. This means that post-treatment blood glucose levels of albino mice were comparable between the 100% Sampaguita leaf extract and metformin.
          Based on findings of the study, the 100% Sampaguita (Jasminum sambac) leaf extract possesses hypoglycemic properties comparable to metformin on the blood glucose levels of dexamethasone-induced hyperglycemic albino mice. The researchers would like to recommend to utilize different concentrations of Sampaguita leaf extracts and determine their effects on the blood glucose level.


1. Azeez, O. H. , Kheder, A. E. . "Effect of Gundelia tournefortii on some biochemical parameters in dexamethasone-induced hyperglycaemic and hyperlipidemic mice." Iraqi Journal of Veterinary Sciences 26(2): 2012. Retrieved from: http://https://core.ac.uk/download/pdf/27200422.pdf
2. Bhujbal, S. S. , Providencia, C. A. , Nanda, R. K. , Hadawale, S. S. , Yeola, R. R. . "Effect of Woodfordia fruticosa on dexamethasone induced insulin resistance in mice" Revista Brasileira de Farmacognosia 22(3): 2012. Retrieved from: http://doi: 10.1590/S0102-695X2012005000020
3. Choudhary, V. . (2017, November 30). Traditional and medicinal uses of mogra (Jasminum sambac). . Retrieved from: http://natureconservation.in/traditional-and-medicinal-uses-of-mogra-jasminum-sambac
4. (2016, November 30). Dexamethasone. . Retrieved from: https://www.drugs.com/dexamethasone.html
5. Diabetes Australia, . (2008, November 30). Steroids & diabetes [Talking diabetes No. 45]. . Retrieved from: https://static.diabetesaustralia.com.au/s/fileassets/diabetes-australia/b8a2f c74-192e-4066-b8f8-aafb34e9df14.pdf
6. Geronimo, L. D. , Sarsoso, S. J. P. . Effects of Jasminum sambac L. (sampaguita) stem extracts on the alloxan-induced hyperglycemic Mus musculus (albino mice). 2016. De La Salle University, . Retrieved from: http://thesis.dlsud.edu.ph/4507/2/BIO%201475%202016.pdf
7. Gowdhami, T. , Rajalakshmi, A. K. , Sugumar, N. , Valliappan, R. . " Evaluation of antimicrobial activity of different solvent extracts of aromatic plant. Jasminum sambac Linn." Journal of Chemical and Pharmaceutical Research 7(11): 136-143, 2015. Retrieved from: http://www.allresearchjournal.com/archives/2015/vol1issue12/PartB/1-11-121.pdf
8. Group, E. . (2012, November 30). The health benefits of Jasmine sambac. . Retrieved from: https://www.globalhealingcenter.com/natural-health/health-benefits-jasmine-sambac/
9. Hess-Fischl, A. H. . (). Prediabetes: How to prevent prediabetes from becoming type 2 diabetes. . Retrieved from: https://www.endocrineweb.com/conditions/pre-diabetes/pre-diabetes
10. Hess-Fishcl, A. H. . (). What is insulin? Important hormone allows your body to use sugar (glucose). . Retrieved from: https://www.endocrineweb.com/conditions/type-1-diabetes/what-insulin
11. Hosseinzadeh, S. , Jafarikukhdan, A. , Hosseini, A. , Armand, R. . "The application of medicinal plants in traditional and modern medicine: A review of Thymus vulgaris" International Journal of Clinical Medicine 6, 636, 2015. Retrieved from: http://doi: 10.4236/ijcm.2015.69084
12. (). How to reverse diabetes naturally. . Retrieved from: https://draxe.com/how-to-reverse-diabetes-naturally-in-30-days-or-less/
13. Jadhav, R. , Puchchakayala, G. . "Hypoglycemic and antidiabetic activity of flavonoids: Boswellic acid, ellagic acid, quercetin, rutin on streptozotocin-nicotinamide induced type 2 diabetic rats" International Journal of Pharmacy and Pharmaceutical Sciences 4(2): 2012. Retrieved from: http://www.ijppsjournal.com/Vol4Issue2/3343.pdf
14. Jain, A. , Sharma, R. , Kumar, A. , Sharma, S. . " Jasminum species: An overview" International Journal of Institutional Pharmacy and Life Sciences 1(1): 256, 2011. Retrieved from: http://ijipls.com/uploaded/journal_files/110809070812.pdf
15. Kalaiselvi, M. , Narmadha, R. , Ragavendran, P. , RaviKumar, G. , Gomathi, D. , Sophia, D. , Kalaivani, K. . "Acute and sub-chronic toxicity effect of Jasminum sambac Linn. oleaceae flower in Swiss albino mice" Pharmacologyonline 3, 517-525, 2011. Retrieved from: http://pharmacologyonline.silae.it/files/archives/2011/vol3/054.kalaiselvi.pdf
16. Khan , M. A. . (2015, November 30). Introduction and importance of medicinal plants and herbs.. . Retrieved from: https://www.nhp.gov.in/introduction-and-importance-of-medicinal-plants-and-herbs_mtl
17. Kongaika, R. . (2016, November 30). List of natural resources in the Philippines. . Retrieved from: https://getawaytips.azcentral.com/list-of-natural-resources-in-the-philippines-12426543.html
18. Kunhachan, P. , Banchonglikitkul, C. , Kajsongkram, T. , Khayungarnnawee, A. , Leelamanit, W. . "Chemical composition, toxicity and vasodilatation effect of the flowers extract of Jasminum sambac (L.)ait. “G. duke of Tuscany”" Evidence-Based Complementary and Alternative Medicine 2012, 2012. Retrieved from: http://doi: 10.1155/2012/471312
19. Felson, S. . (2016, November 30). Natural remedies for type 2 diabetes.. . Retrieved from: https://www.webmd.com/diabetes/natural-remedies-type-2-diabetes#4
20. National Center for , . (2017, November 30). The surprising truth about prediabetes. . Retrieved from: https://www.cdc.gov/features/diabetesprevention/index.html
22. "Philippines seen as ‘diabetes hotspot’." Sun Star Manila. , March 2016. Retrieved from: http://www.sunstar.com.ph/manila/local-news/2016/03/23/philippines-seen-diabetes-hotspot-464154
23. Phanse, M. A. , Patil, M. J. , Abbulu, K. . " Effect of Thespesia populnea Linn. on dexamethasone induced insulin resistance in mice" African Journal of Pharmacy and Pharmacology 8(16): 429-432, 2014. Retrieved from: http://Doi: 10.5897/AJPP09.345
24. Pietrangelo, A. , Cherney, K. . (2016, November 30). The effects of diabetes on your body. . Retrieved from: https://www.healthline.com/health/diabetes/effects-on-body#1
25. Rena, G. , Pearson, E. R. , Sakamoto, K. . "Molecular mechanism of action of metformin: Old or new insights?" Diabetologia 56(9): 2013. Retrieved from: http://doi: 10.1007/s00125-013-2991-0
26. Sabharwal, S. , Sudan, S. , Ranjan, V. . "Jasminum sambac Linn (motia): A review" International Journal of Pharmaceutical Research and Bio-Science 2(5): 108-130, 2013. Retrieved from: http://www.ijprbs.com/issuedocs/2013/10/IJPRBS%20430.pdf
27. Sabharwal, S. , Vats, M. , Sardana, S. , Aggarwal, S. . "Pharmacognostical,physico and phytochemical evalution of the leaves of Jasminumsambac Linn. (oleaceae)" International Journal of Pharmacy and Pharmaceutical Sciences 3(4): 2011. Retrieved from: http://www.ijppsjournal.com/Vol3Issue4/2597.pdf
28. Salikha, A. . (2017, November 30). The national flowers of Southeast Asian nations. . Retrieved from: https://seasia.co/2018/01/28/the-national-flowers-of-southeast-asian-nations
29. Shajones, . (2015, November 30). Re: Sampaguita flower . . Retrieved from: https://athalls.sites.ucsc.edu/2016/10/07/sampaguita-flower/
30. Shetty, A. J. , Choudhury, D. , Rejeesh, , Nair, V. , Kuruvilla, M. , Kotian, S. . " Effect of the insulin plant (Costus igneus) leaves on dexamethasone-induced hyperglycemia" International Journal of Ayurveda Research 1(2): 2010. Retrieved from: http://doi: 10.4103/0974-7788.64396
31. The Flower Expert, . (2015, November 30). Sampaguita. . Retrieved from: https://www.theflowerexpert.com/content/aboutflowers/tropicalflowers/sampaguita
32. Upaganlawar, A. B. , Bhagat, A. , Tenpe, C. R. , Yeole, P. G. . "Effect of Jasminum sambac leaves on serum glucose and lipid profile in rats treated with alloxan" Pharmacology online 1, 2009. Retrieved from: http://pharmacologyonline.silae.it/files/youngresearchers/2009/vol1/001.%20UpagalRevised.pdf
33. Vessal, M. , Hemmati, M. , Vasei, M. . "Antidiabetic effects of quercetin in streptozocin-induced diabetic rats" Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 135(3): 2003. Retrieved from: http://doi: 10.1016/S1532-0456(03)00140-6

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