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A PILOT STUDY ON SINGLE NUCLEOTIDE POLYMORPHISMS OF CATHECHOL- METHYLTRANSFERASE (VALI58MET) AND CYP2D6*10 (PRO34SER) AND OPIOID USE AMONG CANCER PAIN PATIENTS.

Author

Francis O. Javier,
Antonio B. Yap,
Merlina L. Cabrera,
Lyde A. Magpantay,
Cynthia A. Mapua,
Maria Luisa  G. Daroy,
Michael  O. Baclig

Related Institution

St. Lukes Medical Library - St. Luke's Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
St. Luke's Healthcare Journal
Frequency
Semi-Annual
Publication Date
July-December 2016
Volume
11
Issue
2
Page(s)
55-62

Abstract

A hospital-based  cross-sectional  study was conducted to e  aluate  the association between catechol-0-methyltransferase COMT)  and CYP2D6*  I 0 single  nucleotide  polymorphisms (SNPs)  and opioid consumption  among cancer pain patients. COMT  and  CYP2D6*   10 genotyping     was  performed    by polymerase      chain   reaction-restriction        fragment    length polymorphism     (PCR-RFLP).    In  this   study,   there  was  no association   noted  between  COMT  genotype  and dosage  of morphine.  The odds of moderate to high morphine use among patients   with    Val/Val   genotype   were   I. 78  times    higher compared  to those  with Val/Met  genotype.   For CYP206*  10


S   Ps,  there was no association  noted when  various   doses of tramadol     were  compared   against   the  three   CYP206*   10 genotypes      (Homozygous    CIC;     Heterozygous    CIT   and Homozygous  TIT).      In  conclusion,  there  was no association een  in  both  the  pain candidate   genes,  COMT (Vall  58Met) and CYP2D6* l 0 (Pro34Ser) and opioid use among cancer pain patients.


 


Key  words.   COMT;  CYP206*  l O;    Cancer  Pain;   SNPs; Opioids


 


 


 

References

1. Mercadante S,, , Fulfaro F., . "World Health Organization guidelines for cancer pain: A reappraisal." Ann Oncol 16(4): 32-5, 2005

Physical Location

LocationLocation CodeAvailable FormatAvailability
St. Luke Abstract Print Format

 
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