Author
GUINEVERE G. ORTIZ LUIS ,
ANGELO V. POBLETE ,
MA. LOURDES K. CABALUNA
Related Institution
Publication Information
Publication Sub Type
Journal Article, Original
Title
St. Luke's Healthcare Journal
Publication Date
January-December 2017
Abstract
B ac k g ro u nd: I nt ra ve n o u s lido c a i ne infu s i o n ha s be e n r e por te d t o pr ov ide effect i v e ana l gesia in c a n c er pain refracto r y lo o pi oid .
O b j ec ti ve : The ob je ct i v e of t hi s s y s t e m at i c r e view was to esta bli s h ev i dence fo r t he e ff ec ti ven es s a n d s afe t y o f int rave n ou s lid oca in e in fu s i o n in th e m anag e me n t re fr a cto r y ca n cer pa in.
M e t h odology: T hi s i s a s ys t emat i c r ev i ew. A co mpr e h e n sive li te ratu re se ar c h was c on d u cte d u s ing datab a ses in cluding Cochrane L ib ra r y , Me dl ine ( O vid) a nd P ubM e d from J an u a r y 200 1 o Jun e 2 0 1 7 id ent i fy publ i s h e d s t u d i e s on th e effe ct ive n ess i ntra v e n o u s I id oca i neon r efra c tory canc e r p ain in a d u l t p at i e n ts . T he ou t co m e s m e as u red for t h i s r ev i e w we r e p a in r e l ief nd ad v e r se e v e nts.
R e s ult s : Ov e ra ll , h e 3 s t ud i es i n cl u d e d hi s rev i ew
re p o r ted e vide n ce t h at pa r e n te r al l idocaine was we ll - tolerate d a nd provide d rel i ef in o pi o id - re fr actory ca n c e r pa in . T h e r e s u l ts m u s t b e i n t e r pr ete d with c a ut ion g i ven t he i n he r e n t limita ti o n s ofa re tr os p ec t ive qu al it at i ve a n a l ys i s n d a ph ase 2 ra nd o mi ze d c o n t ro ll e d tr i a l.
C o nclu s ion: Wi t h t he li m it e d e r of s t udi e s o n t he e ff ect i vene s s nd safety of i ntrave n ous l id oca i n e i n fusio n fo r opio i d- r efrac t o r y n ce r p ain , t h i s systemat i c r e v i ew hi ghl i ghts t h e need fo r sta nd ar di z e d li d oc ain e a dm inis t rat i o n prot o cols . Lar ge r ra nd o mi ze d cont r o ll ed r ials r e n ee d e d t o e s ta bl is h p a r e nt e r al l ido cai n e ' s effica cy nd s a fe t y i n or d er to m ake i t w id e l y a vai l a b l e.
K e y w o rd s : O p i o id - r e fracto r y , cancer pai n , l id oca in e in fu s i on , p ai n m a n a g e m ent
References
1. van den , Beuken-van , Everdingen, MH. , Hochstenbach , LM. , Joosten, EA , Tjan-Heijnen , VC, . "Update on prevalence of pain in patients with cancer: Systematic review and meta-analysis. " Journal of Pain and Symptom Management 51(6): l070- 90, 2016
2. Carlson , CL. . "Effectiveness of the World Health Organization cancer pain relief guidelines: an integrative review." J Pain Res 9, 515-34, 2016
3. Zech , DF , Grand , S , Lynch, J , Hertel , D , Lehmann , KA . "Validation of World Health Organization guidelines for cancer pain relief: a I 0-year prospective study. " Pain 63(1): 65- 76, 1995
4. Meuser , T. , Pietruck , C. , Radbruch , L. , Stute, P. , Lehmann , KA. , Grond, S . "ymptoms during cancer pain treatment following WHO Guidelines: a longitudinal follow up study of symptom prevalence, severity and etiology. " Pain 93, 247-57, 2001
5. de Wit, R , Loonstra, S, , van Darn , F. , Zanbelt , L. , van Buuren , A , Leehouts , G, . "The Amsterdam Pain Management Tndex compared to eight frequently used outcome measures to evaluate the adequacy of pain treatment in cancer patients with chronic pain. " Pain 9(3): 339-49, 2001
6. Hanks, GW , de Conno , F , Cherny , N, , Hanna M,, M, , Kalso , . " Morphine and alternative opioids in cancer pain: EAPC recommendations. " Br J Cancer 84(5): 587-93, 2001
7. Mercadante , S. , Portenoy , RK. . "Opioid poorly-responsive cancer pain. Part I:clinical considerations. " J Pain Symp Manag 21(2): 144-50, 2001
8. Lee ,, M. , Silverman , S. , Hansen , V. , Patel , V. , Manchikanti ., L. . " A comprehensive review of opioid-induced hyperalgesia. " Pain Physician 14(2): 145-61, 2011
9. Silverman , S . "Opioid induced hyperalgesia: Clinical implications for the pain practitioner." Pain Physician 2009; 12(3 ): 679-84 12(3): 679-84, 2009
10. Currow , DC , Spruyt , O , Hardy, J . " Defining refractory pain in cancer for clinicians and researchers. "
J Palliat Med 15(2): 5-6. , 2012. Retrieved from:
http://PubMed PMID: 22268402.
11. Afsharimani , B , Kindl , K , Good, P , Hardy, I. . " Pharmacological options for the management of refractory cancer pain - what is the evidence?" Support Care Cancer 23(5): 1473-81, 2015
12. Fainsinger , RL , Nekolaichuk , CL . " A CL A " Support Care Cancer 16(6): 547-55, 2008
13. Bruera , E. , Schoeller , T. , Wenk , R. , MacEachern , T. , Marcelino , S. , Hanson, J. . "A prospective multicenter assessment of the Edmonton staging system for cancer pain. " J Pain Symp Manage 10(5): 348-55, 1995
14. Fainsinger , RL. , Nekolaichuk , C. , Lawlor , P. , Hagen , N , Bercovitch , M. , Fisch , M. . " An international multicentre validation study of a pain classification system for cancer patients. " Eur J Cancer 46(16): 2896-904, 2010
15. Trernont-Lukats , IW. , Challapalli , V. , McNicol , ED. , Lau, J. , Carr , DB. . "Systemic administration of local anesthetics to relieve neuropathic pain: a systematic review and meta-analysis. " Anesth Analg 101(6): 1738-49, 2005
16. Ellemann , K. , Sjogren , P. , Banning , AM. , Jensen, TS , Smith, T. , Geertsen. , . " Trial of intravenous lidocaine on painful neuropathy in cancer patients. " Clin J Pain 5(4): 291- 4, 1989
17. Ellemann , K. , Sjogren , P. , Banning , AM. , Jensen, TS , Smith, T. , Geertsen. , . " Trial of intravenous lidocaine on painful neuropathy in cancer patients. " Clin J Pain 5(4): 291- 4, 1989
18. Bruera , E. , Ripamonti , C. , Brennis , C. . "A randomized double-blind crossover trial of intravenous lidocaine in the treatment of neuropathic cancer pain." J Pain Symp Man 7(3): 138-40, 1992
19. Vadalouca, A , Raptis , E. , Moka , E , Zis , P , Sykioti , P. . "Pharmacological treatment of neuropathic cancer pain: a comprehensive review of the current literature. " Pain Pract 12(3): 219-51, 2012