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Antibacterial activity of Euphorbia hirta (Gatas-gatas/Tawa-tawa) against Escherichia coli.


Gilrey-Stanley N. Cortes,
Joselito Marie Ouano,
Patricia Kile N. Samson,
Carlo Angelo  L. Santamaria,
Gillan Mae A. Sayson,
Joaquin Miguel  C. Tirado,
Elvira A. Arong

Related Institution

College of Arts and Sciences - Biology Department - Cebu Doctors' University

Publication Information

Publication Type
Thesis Degree
Publication Date
October 2015


Escherichia coli is becoming more resistant towards pharmaceutical products due to repetitive consumption. Euphorbia hirta has been previously studied and proven to have antibacterial effects against E. coli, hence, it was chosen as part of this research as an objective of finding alternative treatment for E. coli infection. In order to determine the antibacterial effects of Euphorbia hirta, it was tested against Chloramphenicol and each of the zones of inhibition produced on the Mueller-Hinton agar and the significant difference of both ZOI were measured.

 When compared to Chloramphenicol, which had an average zone of inhibition of 24mm, Euphorbia hirta proved to be significantly less effective with only an average of 7mm. Based on the standardized antibiotic sensitivity table from CLSI, Euphorbia hirta was not as effective as Chloramphenicol.

In conclusion, Euphorbia hirta is not to be considered an alternative medication to Escherichia coli infections, as well as an antibacterial agent against Escherichia coli. For future studies on E. hirta and E. coli, it is recommended that antibacterial assays be performed on E. hirta in conjunction with other plant extracts in order to get a bigger scope of Euphorbia hirta's standard zone of inhibition. 


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