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Clinical utility of left ventricular ejection fraction reserve by stress thallium-201 myocardial gated single photon computed tomography among patients with and suspected coronary artery disease.


Herwin John M. Aycocho,
Jerry M. Obaldo

Related Institution

Division of Nuclear Medicine - Philippine Heart Center

Publication Information

Publication Type
Publication Sub Type
Clinical trials/Clinical investigations (RCT
The Philippine Journal of Nuclear Medicine
Publication Date
January-June 2017


BACKGROUND: Coronary microcirculation impairment with sequential decrease in cardiac function is reflected by abnormal left ventricular ejection fraction reserve (LVEFR),which precedes diagnostic evidence of myocardial insult. However, prognostic utility of LVEFR is less, if not least explored. The aim of this study was to evaluate the clinical utility of LVEFR in predicting major cardiac events (MACE) among patients with and suspected coronary artery disease (CAD).
MATERIALS AND METHODS: A retrospective cohort study of 245 patients who underwent stress thallium-201 myocardial perfusion scan (MPS) was conducted. The patients were categorized as having normal or abnormal perfusion scan. Each group was subdivided into normal and abnormal LVEFR groups. All subjects were followed up for any major adverse cardiac events 36 months after MPS through review of hospital records.
RESULTS: There was an overall increase in the likelihood of cardiac events with abnormal LVEFR (i.e., odds ratio of 2.99,p=<0.01). Majority of subjects with abnormal MPS also had abnormal LVEFR showing a significantly lower mean LVEFR (1.17± 7.30 vs. 3.02 ± 7.36p =<0.01).
CONCLUSION: Abnormal LVEFR can be used as an independent predictor of cardiac events which can be observed in subjects with normal and abnormal perfusion scans alike.

Physical Location

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Philippine Council for Health Research and Development Library Box No. 21 Fulltext Print Format

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