Book of Abstracts
Publication Sub Type
CSMC Research Abstract Compendium
BACKGROUND: Abnormal glucose metabolism is a significant determinant in the advent of coronary artery disease. Hemoglobin a1c is an objective measure of glycemic control that is used to diagnose, and assess the risk of microvascular complications in patients with diabetes mellitus. However, its role in predicting coronary artery disease (CAD) in non-diabetic patients remains unclear.
OBJECTIVE: The aim of this study is to determine the association of glycosylated hemoglobin and coronary artery disease in patients without diabetes mellitus
METHODS: Controlled clinical studies were searched in several electronic sources and were included provided they focused on the role of glycosylated hemoglobin as a determinant of coronary artery disease in patients who are never diagnosed with diabetes.
RESULTS: There was an initial sample of 29 citations and 2 controlled clinical trials were finally included in this study (2002 patients). Both studies provided data on baseline population profile, showing no significant difference from one another. Multivariate linear regression was used to test the independent involvement of HbA1c levels to coronary artery disease.
CONCLUSION: A higher level of glycosylated haemoglobin even within the normal range is predictive of angiographically proven coronary artery disease, independent of other cardiovascular risk factors. This conclusion shows a potential role of HbA1c, even in non-diabetic level, in risk stratification and early detection of CAD which may also be helpful to promote preventive measures.