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A Meta-Analysis on the Effect of Warfarin for Atrial Fibrillation in patients with End Stage Renal Disease on Hemodialysis: Is it really stroke preventive?.


Michael Adrian  Mendoza,
William  Chua

Related Institution

Cardiovascular Institute - Cardinal Santos Medical Center

Publication Information

Publication Type
Book of Abstracts
Publication Sub Type
CSMC Research Abstract Compendium


BACKGROUND:  Warfarin has been a standard treatment for prevention of ischemic stroke in patients with atrial fibrillation (AF) based on recent guidelines. However, it has been concluded by recent studies that on End Stage Renal Disease (ESRD) patients with AF, warfarin treatment has conveyed no protection and even ironically increased the incidence of stroke thru enhancement of vascular calcification.  

METHOD: A meta-analysis type of study is conducted to compare the incidence of ischemic stroke in ESRD patients on warfarin and on without any anticoagulant treatment. Outcome of ischemic stroke will be analyzed using Review Manager 5.3 and graphed using a Forrest plot. By web search and by criteria of inclusion/exclusion, five (5) studies were included and analyzed.  

RESULTS: ESRD patient with AF on warfarin tend to have higher incidence of stroke as compared to same population not on any anticoagulation with p value=0.03.   

CONCLUSION: Implementing warfarin does not convey protection from ischemic stroke and probably, by vascular calcification mechanism, ironically promotes more ischemic strokes.   

Physical Location

LocationLocation CodeAvailable FormatAvailability
Cardinal Santos Medical Center - Research Center Abstract Print Format

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