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A Meta-analysis on the use of Intravenous Nicorandil in preventing Contrast-Induced Nephropathy in patients undergoing coronary angiography or angioplasty.

Author

Ryan Paul P. Astudillo,

Related Institution

Cardiovascular Institute - Cardinal Santos Medical Center

Publication Information

Publication Type
Book of Abstracts
Publication Sub Type
Compendium
Title
CSMC Research Abstract Compendium
Date
2014
Page(s)
4

Abstract

BACKGROUND: Contrast Induced Nephropathy is one of the complications of patients undergoing coronary procedures. The exact mechanism causing this type of nephropathy is not yet fully understood. Reactive oxygen radicals and renal ischemia may play a role in the development of contrast-induced nephropathy. The estimated incidence of contrast induced nephropathy after coronary angiography was around 15%. Nicorandil is a novel antianginal drug which has several mechanisms of action. By increasing KATP activation, it prevents accumulation of reactive oxygen species which may help in reducing the incidence of contrast induced nephropathy.   


OBJECTIVES:  The aim of this study is to determine the incidence of contrast induced nephropathy among adult patients with chronic kidney disease given intravenous Nicorandil undergoing coronary angiography or angioplasty.  


METHODS: Each article which was included in the meta-analysis was independently reviewed by the 2 authors to maintain the quality of data gathered using the inclusion and exclusion criteria. Statistical analysis was done using RevMan 5.3.4.  


RESULTS: In the study by Nawa et al. 2011, there was only 1 case of contrast induced nephropathy compared to the control group which had 7 cases. However, in the study by Young-Guk Ko, both treatment arms had similar number of events. Overall, there was no significant difference with respect to the incidence of contrast induced nephropathy in patients given Nicorandil versus control (RR 0.45; 95% CI 0.06, 3.35; p=0.44).  There was no significant difference in terms of the incidence of side effects between the two groups (RR 0.60; 95% CI 0.14, 2.50; p=0.48).   


CONCLUSION:  In summary, Nicorandil did not decrease the incidence of contrast induced nephropathy when compared to saline hydration. There was also no statistically significant difference in terms of developing side effects in both treatment arms. 

Physical Location

LocationLocation CodeAvailable FormatAvailability
Cardinal Santos Medical Center - Research Center Abstract Print Format

 
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