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Clinical profile and prevalence of patients with Non-alcoholic Fatty Liver Disease (NAFLD) at risk of developing advanced fibrosis based on the NAFLD fibrosis score.

Author

Nicodemus Ong,
Diana  Payawal

Related Institution

Department of Internal Medicine - Cardinal Santos Medical Center

Publication Information

Publication Type
Book of Abstracts
Publication Sub Type
Compendium
Title
CSMC Research Abstract Compendium
Date
2016
Page(s)
24

Abstract

INTRODUCTION: Estimates of worldwide prevalence of NAFLD is around 6.3% to 33% in the general population and prevalence of non-alcoholic steatohepatitis (NASH) is lower, ranging from 3 to 5%. Several studies have shown that Asian population have a surprisingly high prevalence of NAFLD despite having significantly lower BMI than other ethnic groups, which may result from ethnic differences in the distribution of body fat, with more central adiposity and visceral fat deposition among Asians. In the Philippines, only a few studies have been published on the profile of patients with NAFLD. In the study of Lusong et al. in Philippine General Hospital from 1999 to 2004 showed a prevalence of 12.2%. This study aims to determine the prevalence and clinical profile of NAFLD patients at risk to develop advanced fibrosis based on the NAFLD Fibrosis score at Cardinal Santos Medical Center (CSMC).  


METHODS: Chart review of CSMC - Wellness Center patients from 2014-2015 was done to note demographics, anthropometric measurements, co-morbidities, and laboratory examination findings. NAFLD was diagnosed based on ultrasonographic findings. Factors that causes secondary fatty liver disease was excluded. Data obtained were analysed using SPSS version 10.  


RESULTS: Of the 1,870 patients who underwent wellness checkup, 734 patients were included in this study. Majority of patients were aged between 41-60 years (64.3%; mean: 50.65); males (68.4%), with a mean BMI of 28.85 (48.1% of patients belong to the Obese I category); 43.6% had hypertension; 59.7% had diabetes mellitus/impaired fasting glucose; most patients had total cholesterol levels <200; Triglycerides < 150; HDL levels between 40-60; LDL levels between 130-159; only a minority had elevated AST (10.5%) and ALT (15%). All included patients were stratified as low probability (score of < -1.455) using the NAFLD fibrosis score.  


CONCLUSION: The prevalence rate of NAFLD at our institution was 39.78% with all patients belonging to the low probability for advanced fibrosis using the NAFLD Fibrosis score. Male sex, obesity, diabetes, with borderline LDL levels were characteristics of our NAFLD patients, with only a minority having elevated liver enzymes. 

Physical Location

LocationLocation CodeAvailable FormatAvailability
Cardinal Santos Medical Center - Research Center Abstract Print Format

 
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