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A meta-analysis on the efficacy of colloid versus crystalloid infusion as prophylaxis against post-operative nausea and vomiting.


Vanessa C. Adorador,
Michael M. Mendoza

Related Institution

Department of Anesthesia and Pain Medicine - Cardinal Santos Medical Center

Publication Information

Publication Type
Book of Abstracts
Publication Sub Type
CSMC Research Abstract Compendium


INTRODUCTION:  PONV is a common yet serious complication as it causes decrease patient satisfaction, prolonged hospital stay, and unanticipated hospital admissions. Prevention rather than treatment would appear to the more prudent choice, and we set out to investigate the efficacy of colloid versus crystalloid infusion as prophylaxis for PONV. 

METHODS:  We performed a literature search using PubMed, Google Scholar, and Cochrane library, and included prospective, randomized control trials which compared the use of colloid versus crystalloid against PONV. Studies were evaluated with regard to risk of bias and quality of study. Three trials were identified and used for analysis. Measured outcomes include incidence of nausea, incidence of vomiting, and incidence of anti- emetic rescue therapy. 

RESULTS:  There was no significant difference in the incidence of nausea (risk ratio 0.96; 95% CI, 0.4 - 2.3; P=0.93), the incidence of vomiting (risk ratio 1.18; 95% CI, 0.32 - 4.36; P=0.80), and the use of anti-emetic rescue therapy (risk ratio 1.07; 95% CI, 0.52- 2.22; P=0.85) between groups. 

DISCUSSION:  Currently existing randomized control studies fail to demonstrate the superiority of colloid infusion against crystalloid infusion as a prophylaxis against PONV. Due to the higher cost of colloid fluids, use of crystalloid fluids for prophylactic hydration might be a more practical approach.  


Physical Location

LocationLocation CodeAvailable FormatAvailability
Cardinal Santos Medical Center - Research Center Abstract Print Format

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