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The role of oxygen-derived free radicals and myocardial reperfusion injury in the total ischemic myocardial burden.

Author

Ramon F. Abarquez Jr.

Related Institution

Division of Education and Research - Philippine Heart Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
ASEAN Heart Journal
Frequency
Semi-Annual
Publication Date
July-December 1993
Volume
1
Issue
2
Page(s)
66-80

Abstract

The total ischemic myocardial burden starts from the production of atherosclerotic plaque initiated by events affecting endothelial integrity. The development of fissure rupture, thrombus formation and the role of vasospastic mechanisms lead to a significant epicardial arterial occlusion. Microvascular occlusion by leucocyte pllead to a no-reflow phenomenon. Even at AMI, spontaneous reperfusion, frustrated phagocyte bursts and vasoactive events produce free radicals to overcome tissue oxygen radical scavengers. Repurfusion injuries causing lethal or non-lethal intracellular damage and/or fatal and non-fatal arrhythmia have been documented in experimental and human studies. Thus, the additive role of anti-oxidants seems to give a promising future in maximizing myocardial salvage at the acute myocardial infarction phase of the total ischemic myocardial burden. 

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Fulltext Print Format

 
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