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Specimen handling and tissue preaparation in pre-analytical phase of HER2 testing at tertiary referral hospitals of Metro Manila.

Author

Marlowe S. Imperial,
Susano B. Tanael,
Jose Ma C. Avila,
Ma. Lourdes A. Tiambeng

Related Institution

Section of Medical Oncology, Department of Medicine - University of the Philippines

Department of Pathology, College of Medicine - University of the Philippines

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Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Acta Medica Philippina
Frequency
Quarterly
Publication Date
April-June 2015
Volume
49
Issue
2
Page(s)
48-53

Abstract

INTRODUCTION: HER2 test result depends on a good quality histological section of the breast specimen. Laboratories that process specimens using sophisticated and molecular testing should receive suitable specimen for more accurate results and less waste of expensive resources.
METHODS: A questionnaire based on the ASCO-CAP Guidelines for HER2 testing was developed and administered to pathologists from the local laboratories of Metro Manila-Philippines tertiary referral hospitals. Questionnaire responses were analyzed using descriptive statistics.
RESULTS: Most laboratories did quality control/quality assessment monitoring for the pre-analytic, analytic,post-analytic and turn¬around time phases. Many transported their specimens from the operating room to the laboratory
CONCLUSION: Even in standardized procedures, small variations in sample processing for IHC and FISH can still occur. Inexperienced laboratories will have greater problems interpreting HER2 status results. Laboratories should look into their system in handling specimens for an accurate HER2 testing towards quality assurance.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 107 Fulltext Print Format

 
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