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Association of coronary flow reserve by dipyridamole technetium-99m sestamibi single photon emission computed tomography with perfusion findings and risk factors for coronary artery disease.

Author

Deverly D. Tumapon,
Jerry M. Obaldo

Related Institution

Division of Nuclear Medicine - Philippine Heart Center

Publication Information

Publication Type
Journal
Publication Sub Type
Clinical trials/Clinical investigations (RCT's)
Title
The Philippine Journal of Nuclear Medicine
Frequency
Semi-Annual
Publication Date
January-June 2015
Volume
10
Issue
1
Page(s)
8-14

Abstract

BACKGROUND: Blunting of coronary flow reserve (CFR) may precede overt ischemia. The study aimed to correlate CFR with perfusion findings and risk factors for coronary artery disease (CAD).
METHODS: Fifty-four consecutive patients underwent dipyridamole-rest technetium-99m sestamibi single photon emission computed tomography (SPECT) on two separate days. CFR was computed as the quotient of myocardial blood flow (MBF= global tissue perfusion divided by arterial input function) at stress and at rest.
RESULTS: CFR was significantly lower in patients with abnormal perfusion vs normals (p=0.005). Reduced CFR was noted in 83% of patients with normal SPECT. Lower CFR was seen in hypertensive patients with left ventricular hypertrophy (LVH) compared to those without LVH (p=0.029); likewise in DM vs no DM (p=0.121). Independent predictors of reduced CFR were age and extent of ischemia.
CONCLUSION: Abnormal perfusion is associated with reduced CFR. In those with normal perfusion, there is a high prevalence of reduced CFR, which may be attributed to the presence of risk factors for CAD and LVH.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box no. 21 Fulltext Print Format

 
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