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Angio-suppressive triterpenoids from Ardisia cf. elliptica (subgenus Tinus) on duck (Anas platyrynchos l.) chorioallantoic membrane.

Author

Dennis D. Raga,
Annabelle A. Herrera,
Consolacion Y. Ragasa

Related Institution

Biology Department, School of Science and Engineering - Ateneo de Manila University

Institute of Biology - University of the Philippines Diliman

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Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Chinese Journal of Natural Medicines
Publication Date
March 2013
Volume
11
Issue
2
Page(s)
128-38

Abstract

The dichloromethane extract of the air-dried leaves of Ardisia cf. elliptica (subgenus Tinus) afforded a mixture of bauerenol (1a), α-amyrin (1b) and β-amyrin (1c). Their structures were identified by NMR spectroscopy. Mixtures of the triterpenes (1a-1c) at ratios of 2 : 2 : 1, 2 : 2 : 3 and 1 : 1 : 1 were tested for their angio-suppressive effects on duck chorioallantoic membrane (CAM). All three ratios were found to be effective in restricting inter-capillary length, while 1a-1c (2 : 2 : 1) was most effective in reducing branch point density with 100% CAM viability and embryo survivability, suggesting a high impact angio-suppressive potential of 1a-1c (2 : 2 : 1).

Physical Location

LocationLocation CodeAvailable FormatAvailability
U.S. National Library of Medicine: PubMed/Medline Abstract External Link (View)
Philippine Council for Health Research and Development Library Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Library Fulltext pdf (Download)

 
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