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Acute toxicity dose and approximate effective dose of calabash (Crescentia cujete) decoction as a hypoglycemic agent in alloxan-induced rabbits.

Author

Muhammad Razul Abdullah,
Rechie  Abear,
Sittie Jebrailyn Amilhasan,
Chris Dy,
Sittie Soriena D. Kundo,
John Edward C. Padiso,
Michael Jan Pimentel,
Haris Rashid,
Rus Cyan Josef E. Rodelas,
Rodessa Charcey Tabunda,
Ruth Kristine Tan,
Melinda C. Tagle,
Herminigilda B. Nartatez,
Ma. Eva San Juan,
Genevieve D. Tupas

Related Institution

Publication Information

Publication Type
Research Project
Date
October 30, 2009-October 30, 2010

Abstract

Diabetes, is define by the level of hyperglycemia. In response to its prevalence, treatment options are being expanded beyond conventional medicine. This study focused on the Calabash fruit (Cresentia cujete) as a blood glucos-lowering agent. It aimed to determined its Acute Toxicity Dose, Effective Dose (ED50) and Approximate Effective Dose (AED). Swiss mice were given an oral dose of Calabash decoction to establish its toxicity. Results classified the fruit decoction category 5 of the OECD guideline, rendering it nontoxic. Alloxan-induced rabbits were used in both ED50 and AED. ED50 Probit analysis of the Fruit was 9.88 mg/kg. AED was found to range from 3.98 to 15.84 mg/kg. Experimental bioassay was conducted and showed blood glucose levels of three groups: Normal Saline Solution, Metformin, and Calabas across time had a mean of 283.00, 261.87 and 241.47 respectively. Evaluation using Post Hoc Paired-huise Test demonstrated Calabash and Metformin had comparable effects.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library RA1250 T87 2010 / PRP369 Fulltext pdf (Request Document)
Philippine Council for Health Research and Development Fulltext Print Format

 
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