Dennis R. de Leon,
Gerard F. Goco
Publication Sub Type
Clinical trials/Clinical investigations (RCT
The Philippine Journal of Nuclear Medicine
The evaluation of tumors in the abdomen and pelvis using PET has its limitations. Physiologic bowel and urine uptake of FDG, as well as benign inflammatory uptake, provides difficulties in image interpretation. Dual-time point PET imaging (DTPI) has been used to differentiate malignant from benign FDG uptake. The purpose of this study is to quantify how useful DTPI is in interpreting suspicious abdominal or pelvic lesions. Methods: A retrospective study of all patients with histologically proven intraabdominal/ pelvic malignancies who underwent DTPI in 2010 were included. Early images were acquired at 60.9 ± 5.6 minutes while delayed images were acquired at 141.7 ± 36.2 minutes after FDG injection. Visual and semi-quantitative analyses (using SUVs) were done on both early and delayed images. Results: DTPI was useful in reaching a more accurate interpretation in 88.6% of suspicious lesions. This was achieved by noting either a change in pattern/configuration of uptake (thus making the lesion likely benign/physiologic) or noting persistence and increase in SUV (1.0 ± 1.3) in the delayed image (making the suspect lesion more likely malignant). Conclusion: Dual-time-point PET imaging is useful in the interpretation of suspect lesions in a majority of cases. Its routine use in the evaluation of patients with intra-abdominal/pelvic malignancies should be considered.