Jose B. Nevado Jr.,
Marcelo B. Severino Imasa
Department of Science and Technology, DOST
Increased blood homocysteine level is a risk fsctor for unstable angina and non-ST elevation myocardial infarction (NSTEMI). This study seek to determine the effect of conventional cardiovascular risk factors - smoking, diabetes, hypertension, advanced age, and dyslipidemia - on homocysteine levels of patients with unstable angina and non-ST elevation myocardial infarction (NSTEMI). Data were taken from 219 patients with unstable angina and non-ST elevation myocardial infarction (NSTEMI) in the past 2 weeks wh owere included in a folic acid supplementation trial. Baseline homocysteine level was positively correlated with age (p=0.008) and significant smoking hidtory, both curtrent and past (p=0.028), but negatively correlated with body mass index (BMI) (p=<0.001). However, there was no significant correlation detected between the risk factors and high homocysteine levels (>16 umol/li). No significant association was detected with diabetes mellitus, hypertension, dyslipidemia and sex. In conclusion, advanced age and smoking are associated with increased homocysteine levels, and BMI is associated with decreased homocysteine levels, in patients with unstable angina and NSTEMI.