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Prevalence and factors associated with insulin resistance among patients with non-alcoholic fatty liver: A prospective study.

Author

Radcliff Y. Cobankiat,
Rosa Allyn Sy,
D Payawal

Related Institution

Department of Internal Medicine - Cardinal Santos Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Internal Medicine
Frequency
Six times a year (6x/year)
Publication Date
November-December 2007
Volume
45
Issue
6
Page(s)
277 - 282

Abstract

OBJECTIVE: To determine prevalence pf insulin resistance among patients with fatty liver.


METHODS: The study employed a cross-sectional survey design among adult patients with fatty liver seen at Cardinal Santos Medical Center for executive check up from September 2003 to September 2004 using a non-probability, purposive, prospective sampling. Ultrasound was utilized to detect patients with non-alcoholic fatty liver who will be prospectively recruited using purposive sampling. Baseline socio demographic and clinical data were collected. Insulin resistance was measured using HOMA-IR. Descriptive statistics was then employed to describe the cases and prevalence of Insulin resistance was computed


RESULT: Of the 24 patients with NAFLD recruited for the study, 15 (67%) were shown to have insulin resistance (IR) as computed by HOMA-IR. Variables noted to be significant and confirmed using correlation coefficient by linear regression in contributing to IR among these patients included waist circumference (P<0.009), waist to hip ratio (p<0.003) and fasting insulin levels (P<0.001).


CONCLUSION: Based on the initial data, prevalence of insulin resistance among patients with NAFLD was high at 62.5%. Factors associated with insulin resistance among patients with NAFLD include higher fasting insulin levels, bigger waist circumference, and waist to hip ratio.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 48 Fulltext Print Format

 
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