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The in vitro bioactivity of Ipomoea muricata (Tonkin) crude extract against methicillin-resistant staphylococcus aureus (MRSA).


Nelia T. Lopez,
Ruel Taclibon,
Delia C. Ongtengco,
Merlyn C. Cruz

Publication Information

Publication Type
Publication Sub Type
Journal Article, Original
Acta Manilana
Publication Date


In searching for potential alternative treatments for diseases caused by the public health threat Methicillin-Resistant Staphylococcus aureus (MRSA), the crude extract of 'tonkin' or Dominican Bean (Ipomoea muricata (L.) Jacq. Family Convolvulaceae) was assayed in vitro against 26 clinical isolates of MRSA. The National Committee on Clinical Laboratory Standards oxacillin-salt agar screen and agar dilution method were used to screen and confirm the resistance of the test isolates. All of the isolates were inhibited by 1 mg of 'tonkin' extract in the disk-agar diffusion assay, producing diameters of zones of inhibition that ranged from 10 mm-15.5 mm. Using the agar dilution method,'tonkin' at a concentration 62.5 ng/ mL,inhibited the growth of all MRSA isolates tested. This is within the good potential level of plant extract concentration for clinical applications.


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