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Effect of brimonidine on anterior-chamber angle in patients with narrow angles .

Author

Johanna Timoteo-Cervantes,
Joseph Anthony Tumbocon,
Ma. Margarita Lat-Luna

Related Institution

International Eye Institute - St. Luke's Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Ophthalmology
Frequency
Semi-Annual
Publication Date
July-December 2011
Volume
36
Issue
2
Page(s)
69-72

Abstract

Methods
Nine eyes with narrow angles were distributed to one of three treatment groups--single topical dose of 0.15% brimonidine tartrate, 0.5% timolol
maleate (positive control), or balanced salt solution (negative control)--in a prospective, single-masked, crossover, comparative trial. The primary outcome measure was anterior-chamber angle at baseline, and 2 and 4 hours after instillation of the treatment drug. Secondary outcome measures were pupil diameter, intraocular pressure (IOP), and anterior-chamber depth and volume. After a two-week washout period, eyes were crossed over to the other treatment modes. All baseline and posttreatment measurements were taken. Repeated analysis of variance (ANOVA) was used for statistical analysis.

Results
Anterior-chamber angle, depth, and volume did not differ significantly for all treatment groups. Brimonidine caused a significant decrease in pupil
diameter, most notably 2 hours after instillation, from baseline of 2.36 ± 0.37 mm to 2.17 ± 0.35 mm. (p = 0.03). There was a significant decrease in IOP from baseline to hour 4 after treatment for both brimonidine (11.4 ± 2.2 to 9 ± 1.8 mm Hg, p < 0.001) and timolol (11.9 ± 2.3 to 9.4 ± 2.1 mm Hg, p = 0.003).

Conclusion
Brimonidine produced a miotic trend with no significant opening of the anterior-chamber angle in patients with narrow angles.

Objectives

This study investigated the effect of brimonidine on the anterior-chamber angle in eyes with narrow angles using noncontact three-dimensional anterior-segment analyzer Pentacam.

References

1. Lo Presti, L , Morgese, A , Ravot, M , et al, . "Ultrabiomicroscopic study of the effects of brimonidine, apraclonidine, latanoprost, and ibopamine on the chamber angle and ciliary body " Acta Ophthalmol Scand (Suppl) 227, 32-34, 1998. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/9972336
2. Gerente, V , Biondi, A , Barbosa, C , et al, . "Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial" J Ocul Pharmacol Ther 23(5): 476-80, October 2007. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/17900228
3. Marchini, G , Babighian, S , Tosi, R , Bonomi, L . "Effects of 0.2% brimonidine on ocular anterior structures" J Ocul Pharmacol Ther 15(4): 337-344, August 1999. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/10463872
4. Hong, S , Ho-Yi, J , Kang , SY , et al, . "Detection of occludable angles with the Pentacam and Anterior Segment Optical Coherence Tomography" Yonsei Med J 50(4): 525-528, August 2009. Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730615/
5. "Nongpiur ME, Sakata LM, Friedman DS, et al. Novel association of smaller anterior-chamber width with angle closure in Singaporeans" Ophthalmology 117(10): 1967-1973, October 2010. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/20541809
6. Kesler, A , Shemesh, G , Rothkoff, L , Lazar, M . "Effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size" J Cataract Refract Surg 30(8): 1707-1710, August 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15313294
7. Thordsen, JE , Bower, KS , Warren, BB , Stutzman, R . "Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes" J Cataract Refract Surg 30(8): 1702-1706, August 2004. Retrieved from: http://www.ncbi.nlm.nih.gov/pubmed/15313293

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 62 Fulltext Print Format

 
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