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Effect of topical ketorolac tromethamine and topical nepafenac on maintaining pupillary dilation during phacoemulsification.


Richard Antanis,
Prospero Ma. Tuaño,
Jay  Vicencio,
Jose Ma.  Martinez,
Lee Verzosa

Related Institution

International Eye Institute - St. Luke's Medical Center

Publication Information

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Ophthalmology
Publication Date
January-June 2011


This is a prospective, randomized, double-masked comparative study involving adult cataract patients given topical NSAIDs (ketorolac or nepafenac) or balanced salt solution (control) prior to phacoemulsification and capsular bag intraocular-lens (IOL) implantation at a tertiary hospital. Horizontal and vertical diameters of pupil were measured at different stages of cataract surgery and the mean values were compared across the three groups.

A total of 47 eyes of 44 cataract surgery patients, 13 males and 34 females, with a mean age of 66.04 ± 8.87 years, were included in the study. The mean horizontal and vertical diameters of the three groups were similar at the start of surgery. Significant differences were seen after IOL implantation, with the nepafenac group having the largest mean diameters in both horizontal (p = 0.012) and vertical (p = 0.012) pupil measurements.

Topical nepafenac has been shown to be a more effective inhibitor of miosis during phacoemulsification and provides a more stable mydriatic effect throughout the surgical procedure compared to topical ketorolac and placebo.


This study compared the effectiveness of prophylactic administration of topical ketorolac tromethamine 0.5% and nepafenac 0.1% on maintaining mydriasis during phacomulsification.


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Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Academy of Ophthalmology Abstract External Link (View)
Philippine Council for Health Research and Development Library Box No. 62 Fulltext Print Format

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