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Five year biochemical outcome utilizing permanent 1-125 prostate seed implant for early prostate cancer.


Domingo Ganzon,
Jason L. Letran,
Manuel P. Yuhico,
Eliseo dela Cruz,
Benjamin L. Ramos Jr

Related Institution

University of Santo Tomas Hospital

Chinese General Hospital and Medical Center

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Publication Information

Publication Type
Publication Sub Type
State of the Art Articles
Philippine Journal of Urology
Publication Date
January-June 2007


Modern prostate brachytherapy using permanent seeds has emerged as an accepted treatment option for localized prostate cancer. Numerous international series have reported excellent biochemical disease free survival with relatively low morbidity. Although this procedure has been widely utilized for localized prostate cancer since the 1980's, it was only in November 2001 that this modality has reached the Philippines. Objective: We aim to present a subset of our patient with localized prostate cancer with at least 2 years follow-up after prostate brachytherapy and compare with large international series. Results: From April 2002 to January 2007, 200 cases of prostate brachytherapy have been performed. One hundred thirty five patients were at least 2 years after the initial implant, although only 101 are evaluable. Using the 1997 ASTRO criteria for biochemical failure, the 5 year biochemical no evidence of disease rate was 91.7 percent for low risk patients, 92.0 percent for intermediate risk patients and 87.0 percent for high risk patients. The procedure is quite well tolerated with minimal adverse events. Conclusion: Our 5 year result utilizing permanent prostate seed implant for management of early prostate cancer is comparable with large international series.

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Philippine Council for Health Research and Development Fulltext pdf (Request Document)

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