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Endothelial response on prostaglandin inhibition after acute limb ischemia in animal models.

Author

Eva Ma Delmo Javier,
Avenilo P Aventura,
MER Ambal,
MG De Joya-Vea,
FA Garcia,
MT  C. Chiaco ,
LD Torres

Related Institution

Department of Cardiovascular Surgery - Philippine Heart Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Cardiology
Frequency
Quarterly
Publication Date
January-March 1999
Volume
27
Issue
1
Page(s)
24-25

Abstract

PURPOSE: This study was undertaken to determine effects of Prostaglandin (PG) synthetase inhibitor on vascular endothelium after acute limb ischemia in animal models.


METHODS: Analysis of vascular endothelial response was made after acute occlusion of the right femoral artery and IV administration of PG synthetase inhibitor in 21 mice. Group A (n=5) received only Heparin and served as controls; Group B (n=8) received Heparin + PG synthetase inhibitor prior to reperfusion and Group C (n=8) received Heparin + PG synthetase inhibitor after reperfusion.


RESULTS: Histoligical analysis of the vascular endothelium showed evidence of minimal intimal injury with smooth appearance of the vessel wall in mice treated with PG synthetase inhibitor in combination with heparin, in contrast to the edematous appearance of the vessel wall in mice given heparin alone.


CONCLUSIONS: This study indicates that addition of PG synthetase inhibitor in treatment of acute limb ischemia reduces injury by maintenance of integrity of vascular endothelium.

References

1. Holmes, D R , Petrinea, D , wester, W , Thompson, R W , Reilly, J M . "Indomethacin prevents elastase-induced abdominal aortic aneurysm in the rate" J Surg Res 63, 305-309, 1996
2. Selike, F W , Boyle, E M , Verrier, E D . "Endothelial cell injury in cardiovascular surgery: The pathology of vasomotor dysfunction" Ann Thorac Surg. 62, 1222-1228, 1996
3. Davies, M G , Hagren, P O . "The vascular endothelium: A new horizon" Ann Surg 218, 593-609, 1993
4. Dauber, I M , Persons, P E , Welsh, C H . "Peripheral bypass induced pulmonary and coronary vascular injury. Association with increased levels mof tumor necrosis factor" Circulation 88, 726-735, 1993

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Box no. 44 Fulltext Print Format
Philippine Council for Health Research and Development Fulltext pdf (Request Document)

 
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