Leila Florento, Maria Cris San Jose, Robert Gan,
Natalie Emper Apaga Related Institution
United Laboratories, Inc.
The Philippine Journal of Neurology
OBJECTIVE: To determine the effects of aerobic exercise training on platelet aggregation, blood coagulation, and plasma lipids in healthy young adults
METHODS: Sixteen healthy, previously untrained subjects (mean age 26 +/- 4 years, 13 females) participated in a six-week (90 mins session, 3x/week) low impact, moderate intensity aerobic exercise program. No dietary modifications were done and subjects were advised to refrain from taking NSAIDs. Platelet aggregation studies using ADP and collagen as agonists, protime international normalized ratio (PT INR), partial thromboplastin time (aPTT), and plasma lipid determinations were performed at baseline, after one bout of exercise, after six weeks of training, and after two weeks of deconditioning
RESULTS: After one bout of exercise, platelet aggregation induced by ADP and collagen ( percent), aPTT and PT INR did not significantly change from baseline levels. After 6 weeks of training, we observed significant inhibition of ADP- and collagen-induced platelet aggregation (17.9 +/- 5.1 and 19.8 +/- 5.0 respectively, p=0.0001) in all subjects, and prolongation of aPTT (41.7 +/- 6.1, p0.01) and PT INR (1.00 +/- 0.11, p0.0001). Although there was a trend towards return to baseline levels, these effects persisted even after 2 weeks of deconditioning Regardless of exercise, training, or deconditioning, concentrations of total cholesterol, triglyceride, HDL-C, LDL-C were not significantly different from baseline levels CONCLUSION: No significant change in lipid profile and blood haemostasis was seen in response to a single bout of exercise. However, regular exercise (training). evoked significant inhibition of ADP- and collagen-induced platelet aggregation, as well as prolongation of aPTT and PT INR values, without significantly altering lipoproteins. The favorable changes induced by training persisted even after 2 weeks of deconditioning IMPLICATIONS OF STUDY RESULTS: Physical activity has been linked to a lower risk and reduced cerebrovascular and cardiovascular mortality. However, the mechanism on how regular physical activity reduces this risk is still unclear. Our study provides clear evidence that biological mechanisms other than control of risk factors underlie the protective effect of regular exercise through its action on platelet function and blood coagulation. This strengthens the case for public health promotion advocating regular physical activity as an inexpensive way of reducing the burden of coronary heart disease and stroke in the general population. (Author)