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Correlation between degree of left ventricular hypertrophy and signal-averaged ECG.


Dexter Dale L. Briones ,
Erlyn C. Demerre ,
Gregorio G. Rogelio

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Publication Information

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
October-December 1998


This is a 2-year retrospective study to determine the correlation between degree of hypertrophy of the posterior wall and interventricular septum and positivity of signal-averaged ECG (SAECTG). Included in the study are patients admitted for executive check-up with 2-D echocardiographic findings of concentric left ventricular hypertrophy (LVH) who underwent SAECG. Echocardiographic findings of LVH were based on the measurement of the thickness of the posterior and interventricular septum of more than 11 mm with left ventricular mass index based on body surface area for males134 gm/m2, females110 gm/m2 and left ventricular mass index based on height for males 140 gm/m, females 98 gm/m. Exclusion criteria were echocardiographic evidence of abnormal wall motion and contractility, echocardiographic evidence of valvular heart disease, presence of ischemia or infarction on ECG, presence of RBBB, LBBB or IVCD. The study population was divided into control group composed of subjects with normal echocardiographic findings with SAECG and a study group with LVH measurement of 12-14 mm and 14 mm. Statistical analysis was done using chi-square test with Yates correction factor, odds ratio and standard deviation. There were 43 subjects each in the control and the study groups. Of the 43 subjects with LVH, 23 or 53% had positive SAECG and 20 or 47% were negative. Compared with the control group with no LVH, only 4 subjects or 9% had positive SAECG and 39 or 91% were negative. A significant p value of .028 was derived which means that patients with LVH have higher likelihood of having a positive SAECG. There were more positive SAECG as the posterior wall becomes thicker however, this was not statistically signficant (p=0.0810). However, as the interventricular septum becomes thicker, there was a higher likelihood of having a positive SAECG with a value of .0226. This study was able to prove a positive correlation between degree of LVH and SAECG.


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