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Prognostic value of P53 gene mutations in axillary node-negative breast cancer.

Author

Bethoven J. Go,
Jose Y. Chua  Jr.,
Larissa Isabel P. Blas,
Conrado C. Cajucom,
Ernesto C. Tan

Related Institution

Department of Surgery - Cardinal Santos Medical Center

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Surgical Specialties
Frequency
Quarterly
Publication Date
July-September 1999
Volume
54
Issue
3
Page(s)
153-156

Abstract

P53 protein is a tumor suppressor gene and its mutation is one of the most commonly found genetic abnormality in human malignancies including breast cancer. The purpose of this retrospective cohort study was to determine the relationship between the presence of p53 and recurrence and death in patients with axillary node-negative breast cancers as well as some clinicopathologic parameters. P53 mutant gene expression was determined by immunohistochemistry in sections from paraffin-embedded tumors in 33 patients with axillary node negative breast cancer with a median follow-up period of 33 months. P53 gene mutation was found in 10 patients. Six of 10 patients (60%) with p53 gene mutation was found in 10 patients. Six of 10 patients (60%) with p53 gene mutation and 2 of 23 without (8.7%) had a recurrence (p=0.006), Fishers test; RR 6.67 (95% CI 1.6127.61). Two of 10 patients (20%) with p53 gene mutation died and none among those without mutation (p=0.156, Fishers test). No association was found between p53 gene mutation and histologic type, family history of breast cancer, and stage of the disease.

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext pdf (Request Document)

 
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