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Correlating diabetic autonomic neuropathy using R-R interval variability with ventricular arrhythmias and dysfunction.


Antonio S. Sibulo Jr,
Stella Marie P. Mabanag

Related Institution

Department of Stress Testing and Cardiac Rehabilitation, Heart Institute - St. Luke's Medical Center

Publication Information

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
April-June 1997


The syndrome of autonomic neuropathy in diabetes occurs at a sub-clinical stage which could predispose to sudden death and cardiac arrest among diabetics. Mortality rate associated with this has been reported to be 50% in 3 years. Attempts to determine the presence of cardiac autonomic neuropathy (CAN) among diabetics are made in this study and correlating this with the occurrence of and predisposition to ventricular arrhythmias and the presence of cardiac dysfunction. There were 34 subjects, 18 diabetics and 17 non-diabetics on whom we performed treadmill exercise test (TET) with deep breathing substituted for hyperventilation in the protocol, Holter monitoring, signal averaged electrocardiogram (ECG), and 2-dimensional echocardiogram (2-D echo). There were 9 who tested positive in the CAN test, mostly females with mean age of 63. Chi square analysis did not show any relation with regard to the presence of autonomic neuropathy and occurrence and predisposition to arrhythmias and that of cardiac dysfunction. This test can be utilized at the bedside and for ambulatory patients in defining a high-risk group of diabetics especially the asymptomatic subset.


1. Zarich, S , Waxman, S , Freeman, R . "Effect of autonomic nervous system dysfunction on the circadian pattern of myocardial ischemia in diabetes mellitus" J Am Coll Cardiol 24, 956-62, 1994
2. Pfeifer, MA , Cook, D , Brodsky, J . "Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man" Diabetes 31, 339-345, 1982
3. Schaffer, SW . "Cardiomyopathy associated with noninsulin dependent diabetes" Molecular and Cellular Biochemistry 107, 1-20, 1991
4. Bennett, T , Fentem, PH , Fitton, D . "Assessment of vagal control of the heart in diabetes; measurement of R-R interval variation under different conditions" British Heart Journal 39, 25-28, 1977
5. Bernardi, L , Rossi, M , Soffiantino, M . "Cross correlation of heart rate and respiration versus deep breathing: Assessment of new test of cardiac automatic function in diabetes" Diabetes , 38, May 1989
6. Roy, TM , Peterson, HR , Snider, HL . "Autonomic influence on cardiovascular performance in diabetic subjects" Am J Med 87, 382-388, 1989
7. Lastimosa, RD , Reyes, RV . "Ventricular late potentials: A new noninvasive marker for sudden death. Clinical applications of signal average electrocardiography" Phil J Cardiovasc Med 4(2): 30-34, 1991

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