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The role of docosahexaenoic acid in milk formulas on the spatial working capacity of young white mice.

Author

Philip Conrad M. Acop

Related Institution

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Journal of Pediatrics
Frequency
Quarterly
Publication Date
October-December 2005
Volume
54
Issue
4
Page(s)
209-214

Abstract

OBJECTIVE: To determine if male mice maintained on DHA fortified milk formula develop better spatial working capacity than male mice maintained on non-DHA fortified milk formula.


DESIGN: Randomized double-blind placebo-controlled experimental study.


SUBJECTS: Forty-five 5-week old male white mice.


METHODS: The subjects were randomly assigned to one of the three groups. Subjects were fed standard rodent diets supplemented with DHA-fortified milk formula, non DHA-fortified milk formula and standard rodent diet. Spatial learning using a T and 8-arm radial maze was then determined using the variables of time and errors made prior to task completion after handling and training. Trial runs were done every three days.


MEASURES: Repeated analysis of variance was used to determine differences in task completion between treatment groups. Independent T-test was done to determine when the treatment groups differed. All statistical tests used to analyze the data were two-tailed at alpha = 0.05 level of significance.


RESULTS: Results revealed not significant difference for DHA fortified and non-DHA groups from the placebo group when time to complete the task was considered. The group maintained on a diet supplemented with a non-DHA fortified milk formula had less error days compared to the placebo group.


CONCLUSION: These results suggest that DHA fortified milk formulas do not improve spatial working capacity in mice. (Author)

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