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A comparative study of the efficacy of formulated Tinospora rumphii Boerl. lotion and Crotamiton in the treatment of scabies in children.


Jean Llamasares-De Franci,
Marie Stephanie Yoro

Related Institution

St. Luke's Medical Center, Quezon City, Metro Manila, Philippines

Publication Information

Publication Type
Sub Type
Journal Article, Original
Philippine Journal of Pediatrics
Date of Publication
October-December 2005


BACKGROUND: Scabies is a common contagious skin infestation in children by the mange mite Sarcoptes scabiei, which is usually contracted by close personal contact, overcrowding, close living quarters and by the use of contaminated towels, bed linen and clothing. A number of effective treatments have been developed however these have been unavailable to most of the affected population due to cost and toxic effects.

GENERAL OBJECTIVE: To confirm the established efficacy of Tinospora rumphii Boerl against scabies as compared to the standard treatment of choice, 10 percent Crotamiton lotion.

METHODOLOGY: A total of 55 subjects were randomly included in this double-blind clinical trial and grouped for treatment accordingly: 30, with Tinospora rumphii lotion (experimental); 15, with standard treatment of Crotamiton lotion (positive control); and 10, with placebo. Patients were treated once daily for three to five days followed by a 5-day rest period and then a second cycle of scabicide application.

RESULTS: All Tinospora-treated subjects responded as follows: 33% showed excellent response to treatment, 160% good response and only 7% fair response to the experimental treatment regimen. In reference to statistical evaluation, there is no significant difference in the efficacy of the formulated makabuhay lotion and Crotamiton but showed significant improvement of lesions with both scabicides in comparison to placebo.

CONCLUSION: The study confirms the anti scabies property of Tinospora rumphii Boerl. and provides an affordable alternative to costly, and potentially toxic drugs in the treatment of scabies in children.


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