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An evaluation of the anti-inflammatory properties of Mikania Cordata (Burm.F) B. L. Robinson.

Author

Kevin D. Croft

Related Institution

Research for the Natural Sciences - University of Santo Tomas

Publication Information

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Acta Manilana
Frequency
Annual
Publication Date
1990
Volume
38
Page(s)
75-81

Abstract

The anti-inflammatory action of the purified extract of Mikania cordata (Burm.F) B. L. Robinson was confirmed in two in-vivo test systems. The system significantly suppressed exudate volume and leukocyte migration in the carrageenan-induced pleurisy model at an oral dose of 200 mg/kg. A dose-dependent inhibition of mouse paw edema was observed with an ID50 of 100 mg/kg. These in-vivo anti-inflammatory responses exhibited by the plant extract are consistent with the biochemical activities displayed by one of its constituents, scandenolide. Scandenolide has shown to potently inhibit the synthesis of the inflammatory mediators leukotriene B4 and platelet-activating factor. These results are suggestive of the therapeutic potential of the plant as a crude anti-inflammatory drug.

References

1. Quisumbing, ES . "Medicinal Plants of the Philippines. Katha Publsihing Company Quezon City, Philippines" , 1978
2. Ysrael, MC , Croft, KD . "Acta Manilana" 37, 65, 1988
3. Ku, EC , Raychaudhiri, A , Ghai, G , Kimble, EF , Lee, WH , Colombo, C , Dotson, R , Oglesby, TD , Wasley, JWF . "Biochimica et Biophysica Acta" 959, 332, 1988
4. Winter, CA , Risley, EA , Nuss, GW . "Proc Soc Exp Biol Med" III, 544, 1962
5. Salmon, JA , Higgs, GA . "Brit Med Bull" 43, 285, 1987
6. Braquet, P , Touqui, L , Shen, TY , Vargaftig, BB . "Pharmacol Rev" 39, 97, 1987
7. Piper, PJ , Samhoun, MN . "Brit Med Bull" 43, 297, 1987
8. Bird, J , Giroud, JP . "J Pharmacol Methods" 14, 305, 1985

Physical Location

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 108 Fulltext Print Format

 
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